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Measles virus-based COVID-19 vaccine for routine immunization against both, proposed in new study


A bivalent measles-based COVID-19 vaccine could be a capable solution to address two significant public health threats.

Illustration of vials of COVID-19 vaccine. Image: Igor Golovniov/SOPA Images

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A measles-virus-based COVID-19

vaccine would possibly be capable to forestall each COVID-19 and measles, based on a brand new examine. As per the study authors, a measles-virus-based COVID-19 vaccine could possibly be administered as a part of routine measles immunization schedules.

In the study, published in the journal PNAS, researchers report a COVID-19 vaccine candidate based mostly on a live-attenuated measles virus.

SARS-CoV-2, the virus that causes COVID-19 , has killed greater than 1 million folks worldwide, underscoring the urgent want for an effective vaccine.

Michael Muhlebach and colleagues explored the opportunity of utilizing a live-attenuated measles virus as a vector for a coronavirus vaccine. The authors inserted the gene for the SARS-CoV-2 spike protein into the genome of a measles virus pressure utilized in measles vaccines.

Sera of mice or hamsters vaccinated with this recombinant virus contained antibodies able to successfully neutralising SARS-CoV-2 and measles virus.

Cytotoxic T cells from vaccinated mice selectively killed cells expressing SARS-CoV-2 spike protein upon stimulation with the spike protein.

Antibody and cytokine ranges in vaccinated mice had been in step with a Th1-biased immune response, suggesting a low danger of immunopathologies similar to antibody-dependent enhancement and enhanced respiratory illness.

In hamster and mouse fashions, vaccinated animals exhibited decrease viral hundreds and fewer extreme pathology following an infection with SARS-CoV-2 than unvaccinated animals.

Updated: December 2, 2020 — 6:58 am

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